Zinc deficiency is frequently observed in patients suffering from chronic inflammatory bowel syndromes such as ulcerative colitis and Crohn’s disease and those who suffer from infectious diarrhea. Furthermore, it is commonly observed in vegetarians as the bioavailability of zinc is less in vegetables when compared to non-vegetarian foods. It is shown that vegetarians often consume legumes rich in phytates, which inhibit zinc absorption from the foods. The risk of insufficiency is high in pregnant and lactating women because of increased dietary requirements by the fetus and feeding. Zinc deficiency is reported to induce dysfunction of the reproductive organs such as testes and ovaries, induce short stature, poor immune responses, and overall impaired growth in children. The inadequacy of zinc leads to loss of hair and poor tissue repair. Its shortage also results in a loss of ability to taste and smell. In addition, its insufficiency is shown to induce loss of appetite, weight loss, and lethargy. Overall, zinc deficiency is shown to impact human health and well-being negatively.
Antiacids and foods containing substantial levels of calcium, magnesium, or aluminum (antacids) reduce alendronate uptake. Therefore, after taking alendronate, wait at least 30 minutes before consuming dairy products or consuming the supplemental or medicine.
There is no information on highly active vitamin D mimics or fluorides. Medications should not be given at the same time.
HRT (hormone replacement treatment) using estrogens/progestins or raloxifene may provide an additional therapeutic benefit in postmenopausal women with osteoporosis, but no complications have been observed. As a result, the pairing is viable but contentious.
Alendronate’s biological activity is increased by intravenous ranitidine. However, there are no recognized clinical implications.
The use of non-steroidal anti-inflammatory drugs (NSAIDs) and alendronate together may raise the risk of stomach ulcers. This is because both of these medications can upset the mucosa of the upper gastrointestinal tract.
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