Type 2 diabetes is a major worldwide health issue and has a complicated origin, including several interactions between hereditary and environmental factors. Insulin resistance in peripheral tissue is significant to the progression of the disease. Specific kinds of dietary fatty acids may lead to insulin resistance. Trans fatty acids (TFAs) are common in the Western diet and are produced by the transition of polyunsaturated fatty acids by hydrogenation. When the number of calories taken exceeds the number of calories utilized for energy, the excess calories are stored as fat, also known as adipose tissue. The relation between fatty acid and diabetes is as follows:
Adipose tissue may be burnt for energy, but it also naturally produces hormones, fatty acids, and proinflammatory cytokines.
As adipose tissue accumulates, so does the fatty acid release, hormones, and proinflammatory cytokines.
Insulin resistance can occur as a result of the high production of poor inflammatory cytokines.
Adipose tissue-released proinflammatory cytokines cause persistent low-grade inflammation. Chronic low-grade inflammation, over time, disrupts normal insulin signaling pathways. The quantity of insulin typically produced by the pancreas becomes insufficient for optimal glucose absorption. When this occurs, the pancreas normally responds by manufacturing more insulin, ensuring that glucose absorption is unaffected. In some people, the pancreas stops producing enough insulin to overcome the blocked pathways, resulting in insulin resistance.
Limiting the intake of trans-fats
Trans fats are found to be linked to diabetes, cancer, and heart disease. Thus, it is best to minimize trans fats consumption. Partially hydrogenated oils may be found in fried food, margarine, and baked goods, including pie crusts, pastries, pizza dough, and biscuits. By checking the food nutrition information, one can verify trans fats and partly hydrogenated oils in the meal before consumption. Trans fats consumption should not be more than 1% of the total calorie intake. Natural trans-fats found in meat and dairy products are considered safe only when eaten at the recommended levels. Artificial trans-fats, on the other hand, should be avoided because they have been related to a variety of detrimental consequences.
Consuming more unsaturated fats, such as canola, a few varieties of nuts, flaxseed, maize, safflower oil, and sunflower oil, which has monounsaturated or polyunsaturated fatty acids, can lower total cholesterol and boost high-density lipoprotein HDL cholesterol levels. People are now aware of the detrimental consequences, and studies indicate that trans fatty acids have been reduced in the modern diet.
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